WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF IMDOMETHACIN BY WET GRANULATION METHOD

Dr. Amit B. Patil*, Dr. Vikas Jain, Dr. D. V. Gowda and Shweta Betala

ABSTRACT

The main aim of the study was to develop sustained release matrix tablet of Indomethacin by wet granulation technique. Indomethacin is a non- steroidal anti-inflammatory drug and COX inhibitor. By wet granulation method, all the ingredients were taken and passed through sieve no. 40 and granulated by passing through sieve no. 25, the matrix tablet were compressed by using 10 station Rimek mini press. The preparation was evaluated for micromeritics properties such as bulk density was achieved on an average 0.424 gm/ml, tapped density was 0.494 gm/ml, average Carrs’s index 1.214, and angle of repose 28.136º. Followed by physicochemical properties i.e. hardness test 4.93 kg/cm3, weight variation 199.44 mg, friability 0.256%. The percentage drug liberated was found between 83.02% to 98.19% due to the various concentration of HPMC K100M. The stability study, shows that percentage drug content determined periodically at a temperature of 400C at 75% RH evaluated at different time intervals, the control sample and test sample are kept at different storage condition at different RH. The granules show good flow properties and test performed are within standard limits. The stability study show that preparation was found to be stable. Drug release studied was carried out in 0.1N for 1.5 hours and till 12th hour in 7.4 pH Phosphate buffer. The release suggested that the formulations FA to FE showed a relationship as decrease in drug release as increase in concentration of HPMC K 100, where FA had the lowest concentration and FE having the highest concentration.

Keywords: Indomethacin, Sustained release, Wet Granulation, HPMC K100, Gaur Gum.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More