WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

COCRYSTAL: A REVIEW ON PHARMACEUTICAL CORYSTALS DESIGN AND PREPARATION

*Sonali R. Devne, Vidya N. Kapse and Dr. Pramod L. Ingale

ABSTRACT

Poor dissolution rate, solubility, bioavailability, chemical stability and moisture uptake are problems associated with most of the active pharmaceutical ingredients. Various approaches have been used for enhancement of solubility of poorly aqueous soluble drugs, Pharmaceutical cocrystal is a reliable method to modify above physicochemical properties without alternating their pharmacological behavior, but success of these approaches depends on physical and chemical nature of molecules being developed. Cocrystallization of drug substances offers a great opportunity for the development of new drug products with superior physicochemical properties such as melting point, tabletability, solubility, stability, bioavailability and permeability, while preserving the pharmacological properties of the active pharmaceutical ingredient. Cocrystal is a stoichiometric homogeneous multicomponent system connected by non-covalent interactions where all the components present are solid under ambient condition. This review article presents a systematic overview of pharmaceutical cocrystals. Differences between cocrystals with salts, solvates and hydrates are summarized along with the advantages of cocrystals. The theoretical parameters consider during selection of coformers and screening of cocrystals have been summarized and different methods of cocrystal formation and evaluation have been explained.

Keywords: Cocrystals, coformer, electrospray.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More