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Abstract

MORBIDITY AND MORTALITY OF ALCOHOLIC LIVER DISEASE AND ITS CORRELATION WTH TYPE, AMOUNT AND DURATION OF ALCOHOL CONSUMPTION

Srujana Vadla*, Akshara Ebusi, Naveena Chinthalapudi and Dr. Devender Kodati

ABSTRACT

Background and objectives: Alcoholic liver disease is a spectrum of clinical illness and morphological changes that range from fatty liver to hepatic inflammation and necrosis (alcoholic hepatitis) to progressive fibrosis (alcoholic cirrhosis). It is a result of over consuming of alcohol that damages the liver, build up of fats, inflammation and scarring. It can also be fatal. Hepatic encephalopathy, ascites and perotinitis are the complications of the alcoholic liver disease. The main aim of the study was to assess and compare the disease progression and mortality in Alcoholic liver disease patients in correlation with the type, amount and duration of alcohol intake. Methodology: A clinical based prospective and observational study by using patient medical records and the other relevant data was collected personally in a properly designed case report form. Results: During the study period 254 patients were included. The age group of 30-50 years was more in number. All the patients included were alcoholic. Majority of the patients consume Whisky > 60gm/day over a period of 15-20years. The laboratory parameters like albumin, bilirubin, prothrombin time was increased and abnormal. MELD was calculated and it was found 25.196% of patients were at the risk of severity and 42.125% of patients have improved quality of life because of cessation of alcohol. Life expectancy or mortality was calculated by using child pugh score for 50 patients and we found 18 patients (42.85%) with score 5-6, 21 patients (49%) with score 7-8, 3 (7.14%) patients with score 9-11. Our study shows that there is a moderate correlation between duration of alcohol intake with severity of disease and there may be possibly no correlation between amount of alcohol intake with disease severity. Conclusion: Only counselling may not effective to maintain the abstinence. Counselling along with de addiction therapy is effective in maintaining the abstinence and decreasing the relapse rate in alcoholic liver cirrhosis patients. There is a greater correlation between duration of alcohol intake with severity than that of disease severity with quantity of alcohol. Cessation of alcohol has improved quality of life of many patients.

Keywords: Liver Cirrhosis, Alcoholic liver disease, Child pugh score, model for end liver disease (MELD).


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