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Abstract

ENHANCEMENT OF BIOAVAILABILITY OF VALSARTAN THROUGH NANOCRYSTAL FORMULATION

Sudha, Dr. Sudipta Saha and Neha Katiyar*

ABSTRACT

The aim of the present study was focused on the development of nanocrystals of valsartan, an antihypertensive drug to be administered through oral route. Five formulations (F1, F2, F3, F4 & F5) of nanocrystals were prepared containing valsartan. Nanocrystals was prepared by antisolvent precipitation method. Prepared valsartan containing nanocrystals were evaluated for particle size, shape, surface morphology, in-vitro drug release and solubility studies. The particle size was found to be between the range of 230nm- 950nm, the particles were uniform, spherical in shape. The drug showed better release rate in comparison to conventional dosage form. All the formulation showed better result in terms of stability. Among the five formulations the best result were found with F1 formulation of valsartan. It can be concluded that for oral preparation a better solubility and bioavailability can be achieved by use of nanocrystals formulation of drug which has poor solubility.

Keywords: The aim of the present which has poor solubility.


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