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Abstract

ANTI-STAPHYLOCOCCAL COMPARATIVE STUDY OF PHALERIA MACROCARPA (SCHEFF). BOERL FRUIT AND RED GUAVA ((PSIDIUM GUAJAVA) LEAF ETHANOLIC EXTRACT

Sri Agung Fitri Kusuma*, Retnowanti Khairunnisa, Niko Tanzillafitsi, Mia Resmiati, Dadan Suryasaputra

ABSTRACT

Objective: This study was purposed to compare the antistaphylococcal strength between Phaleria macrocarpa (Scheff). Boerl fruit ethanolic extract and red guava leaf ethanolic extract against Staphylococcus aureus ATCC 25923, using chloramphenicol as antibiotic standard. Methods: The comparative test was conducted by evaluating the concentration of each extract and chloramphenicol to generate the same diameter of inhibition against S. aureus ATCC 25923. The comparative study was carried out using the agar diffusion method by utilizing perforation method. The diameter data, then plotted to form an inhibition curve against log concentration of the extract or chloramphenicol. The anti-staphylococcal activity of each extract, then calculated and compared with the chloramphenicol strength to obtain the comparative value. Results: The antibacterial activity of chloramphenicol was the strongest then both extracts. However, the P. macrocarpa fruit extracts showed stronger antistaphylococcal against S. aureus ATCC 25923 that of red guava leaf extract. To produce the same inhibitory diameter, chloramphenicol only needed 1 unit, whereas P. macrocarpa fruit extracts and red guava leaf extract needed 51.408 and 1,002.37 units, respectively. Conclusion: The fruit extract of P. macrocarpa fruit extract is more promising to be a medicinal candidate for staphylococcal infections than red guava leaf extract.

Keywords: Comparative, Phaleria macrocarpa (Scheff). Boerl, Staphylococcus aureus ATCC 25923, red guava, chloramphenicol.


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