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Suchita. G. Waghmare*, Dr. Satish. B. Kosalge, Rasika R. Nikhade, Shweta U. Kannao


Transdermal drug delivery system is one of the important drug delivery system. Skin is the main target of topical and transdermal preparations. The aim of transdermal drug delivery system is to cross the stratum corneum. Ethosomes are noninvasive delivery carriers that enable drugs to reach the deep skin layers and the systemic circulation. Now a days vesicles are used as cellular communication medium. Use of Ethosomes as vesicle widely spread. Ethosomes are the ethanolic phospholipids vesicles which are used mainly for transdermal delivery of drugs. Composed of hydroalcoholic or hydro/glycolic phospholipids in which the concentration of alcohols is relatively high. The high concentration of ethanol brings increase in fluidity of lipids hence increase in permeability of the skin and improves the drug penetration. Ethosomes formulation can contain many dugs. Ethosomes have higher penetration rate through the skin as compared to liposome so they can be used widely in place of liposome. Ethosomes have become an area of research interest, because of its enhanced skin Permeation, improved drug delivery, increased drug entrapment efficiency etc. The high concentration of ethanol makes the Ethosomes unique and Useful for transcellular delivery, delivery of hormones, antiarthritis, anti-HIV etc.

Keywords: Ethosomes, Ethanol, Transdermal delivery, Phospholipids, Vesicle.

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