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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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*Dr. M. Anuradha, Dr. K. H. Vasudevanaidu, Dr. N. Suneetha


Back ground: Nosocomial infections, being commonly caused by Pseudomonas aeruginosa, Klebsiella, Proteus, Staphylococcus etc., are responsible for prolonged hospital stay by the vulnerable hosts badly affecting the hospital economy .Multidrug resistance has become one among the great human life threatening problems, we may be left with no effective drug in near future if this phenomenon continues. It is an ongoing process, to curtail Hospital acquired infections to minimum possible ,consisting of effective surveillance of hospital hygiene through biohazardous waste management team, effective infection control team in order to know the emerging epidemiological strains,their sensitivity pattern ,awareness about cost effective drugs with minimal side effects all through effective practical implementation by the dedicated hospital authorities and their sub staff. Here a study is taken to know the prevalence of resistant strains of Pseudomonas aeruginosa in a tertiary care hospital, Tiupathi. Materials & methods: Nosocomial infections are identified by thorough clinical history. Further they were studied for specific pathogen by various biochemical tests and isolation by using appropriate culture media. Among them Pseudomonas aeruginosa is identified by using King’s medium and by its specific bluish green pigmentation. (pyocyanin). Among 330 samples collected from different nosocomial infections such as P.O wound infection, burns infection, UTinfection, bronchial fluid, Otitis externa, Pseudomonas aeruginosa were 72,Klebsiella pneumonia were 58,Staphylococcus aureus were 50,Proteus were 28,other species 8 total being 218,culture negative samples were 112.Further Pseudomonas aeruginosa is studied for imipenem resistance using PCR . Result: Among 218 culture positive strains 72 were due to P.aeruginosa (33.02%), these infections were found to be more common in males age group 50 to 60 (37.2%) .i.e., 24 cases.Antibiotic senstitivity shows. Amikacin(58.33%) sensitive, Gentamycin(42%) Imipenem (84.72%) piperacil+ tazobactum (77.77%) Ceftazidime(54.16%) Cefotoxime(40%). Out of 72 pseudomonas aeruginosa strains 11 strains were resistant to imipenem they were further studied for molecular characterization by PCR. Conclusion: Because of rapidly emerging antibiotic resistance among different nosocomial pathogens there is essential requirement for antibiotic policy in hospitals. Knowledge of sensitivity pattern and molecular characterization of the resistance genes of nosocomial infections is useful for their epidemiological control.

Keywords: Pseudomonas aeruginosa, Klebsiella, Proteus, Staphylococcus.

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