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*Dr. Thusitha Sivachchelvan (MD-S) (Ind)


The Siddha system of medicine is the oldest in ancient India and was derived by Tamil Siddhars or spiritual scientists of Tamilnadu. In Siddha system, herbs, metals, minerals and animal origin are used as medicines since thousands of years. This research is toxicity study on siddha drug- “surangusa parpam” this drug ingredients are: Manosilai (Arsenic disulphide), Milagu (Piper nigrum) and Sangu (Conch). This research drug is reference from; Anubogavaithiyanavaneetham Part III. Evaluate the Safty profile of Surangusa parpam in in-vivo model is main objective of this research. In this research findings are, physicochemical analysis of Surangusa Parpam, the pH was found to be 6.7. This shows it is slightly acidic and loss on drying at 1050C was 8.21 % w/w. In HR SEM analysis, the particle size of Surangusaparpam was found to be 1-3 (micron). In ICP-OES study, heavy metals like As, Pb, Cd, Hg were found below detection limit (WHO guidelines) in Surangusaparpam. It also shows the presence of Calcium, Iron, Potassium, Magnesium, Sodium, Sulphur, Phosphorus and zinc. In acute oral toxicity study (OECD-423), there were no abnormal signs developed in all test groups. No mortality was observed in all groups. In 28 days repeated oral toxicity study (OECD-407), the experimental animal’s blood and histopathological study was evaluated and results were normal in control, Low dose, Mid dose and High dose groups. The kidney shows tubular casts in all test groups. The liver shows mild focal degeneration and mild bile duct hyperplasia in high dose group. From the above results, the drug shows minimum toxicity in high dose groups. Therefore, the indented adult dose of Surangusa Parpam becomes safe for human administration.

Keywords: Manosilai (Arsenic disulphide), Milagu (Piper nigrum) Sangu (Conch) and Surangusa Parpam.

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