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D. Uma Sankar*, Madhuri Latha Thadanki and P. Lavanya


The objective of the present study was preparation, formulation and in vitro evaluation of sustained release Zolmitriptan tablets by using natural polymers. The basic rationale of SR is to alter the pharmacokinetics and pharmaco dynamics of pharmacologically active moieties by using novel drug delivery system or modifying the molecular structure and or physiological parameters inherent in a selected route of administration. Administration of a drug in a conventional dosage form [except via intravenous infusion at a constant rate] often results in 'see – saw' pattern of drug concentration in the systemic circulation and tissue compartments. Zolmitriptan is an anti migraine drug and has a short half life of 3hr. The objective of the present work was formulating a sustained release dosage form of Zolmitriptan by using different percentages and grades of release rate controlling polymers like Ethyl cellulose, Sodium alginate, Sodium carboxy methyl cellulose (10%,15%,20% respectively) by direct compression method. The present study was concerned with the development of the sustained release matrix tablets, which after oral administration were designed to prolong the duration of action. Different percentages of ethyl cellulose 20% was associated with decrease in the overall cumulative drug release rate, the higher viscosity polymer had seen to inhibit the initial burst release of Zolmitriptan. All the prepared formulations were evaluated for thickness, hardness, friability, weight variation and in-vitro drug release. Thus, we conclude that from among all the developed formulations F7 formulation controls the drug release for longer period of time over 8hrs when compare to other formulations. The physicochemical evaluation of the prepared tablets was found within the standards of Pharmacopoeia limits.

Keywords: Zolmitritan, sustain release, pharmacokinetic parameters, Pharmacopoeia limits.

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