Abstract

ACUTE TOXICOLOGY AND NEUROBEHAVIORAL STUDIES ON A NEW 7-AZAINDOLE DERIVATIVE

Nausheen H Siddiqui, Arshad Arain, Zafar .S.Saify, Iqbal Azher, Shazia Haider and Zafar A Mahmood*

Abstract

In view of the biological significance of 7-Azaindole containing compounds, we report the synthesis and the evaluation of 1-methhyl - 4-{1H-pyrrol [2, 3-b] pyridine-3-yl-1, 2, 3, 6-tetrahydropyridine (A1) for acute toxicological effects and neurobehavioral studies using animal module. The compound 1-methhyl -4-{1H-pyrrol [2, 3-b] pyridine-3-yl-1, 2, 3, 6-tetrahydropyridine (A1) was synthesized in laboratory and subjected to acute toxicological observations. The compound was investigated with emphasis to determine the LD50 and to observe neurobehavioral effects in rats and mice. Six dose levels, i.e., 10, 25, 50, 75,100 and 125 mg/kg for rats was selected for the animal model. The LD50 was determined by Arthmatic method of Karber. Prominent signs and symptoms of toxicity was observed. Data plotted using functional observation battery method indicated increase in severity with the increase of dose. The study revealed that 1-methhyl -4-{1H-pyrrol [2, 3-b] pyridine-3-yl-1, 2, 3, 6- tetrahydropyridine (A1), a 7-Azaindole compound as neurotoxic.

Keywords: 7.Azaindole, LD50, Neurobehavioral studies, Arthmeic method of Karber, Functional Observational Battery.