Abstract

BINDING POTENTIAL OF METHYL 3Î’- HYDROXYLBISNORELLOCHOLANOATE WITH HER 2 FOR AN EFFECTIVE TREATMENT OF BREAST CANCER

S. Dorathy Selva Jeba Pritha* and S. Karpagam

Abstract

Breast cancer is prevailing among the women at the rate of 18% of total population worldwide. In the study Coconut shell oil was used to treat breast cancer MCF cell lines. The Coconut plant is also knows as Kalpa Viriksha in India which means the tree gives all the necessities of human life. It is rich in alkaloids, carbohydrates, phenols, tannins, flavonoids, aminoacids, quinines, terpenoids, oxalate and carboxylic acids. The antiproliferative activity of Coconut shell oil was performed by 0.5% 3-(4, 5-Dimethyl-2-thiazolyl)-2, 5-diphenyl-tetrazolium bromide (MTT) method. The highest non-toxic concentration was recorded at 125μg/ml concentration. Molecular docking was predicted using Autodock and Autodock Vina in the PyRx platform on Human Epidermal Growth Factor Receptor 2. The molecule, Methyl 3β-hydroxylbisnorellocholanoate obtained from Coconut shell oil has successful and potential binding with the target molecule. Hence, this may be a potent lead molecule for the treatment of breast cancer and further clinical confirmation is needed to prove it as a valid drug.

Keywords: Coconut shell oil, breast cancer, antiproliferative, molecular docking, Methyl 3?- hydroxyl- bisnorellocholanoate.