Abstract

TASTE MASKING OF BITTER DRUGS BY USING ION EXCHANGE RESIN METHOD

Naykodi Pradnya S.*, Bidkar Shital J., More Komal V. and Dighe Ajinkya D.

Abstract

The various organoleptic properties such as taste, smell, texture also these are important factor in development of oral dosage forms. The taste is the major factor that affect the patient compliance and product quality. Acceptability of any dosage form mainly depends over its taste i.e. mouth feel. Drug molecule interact with taste receptor on the tongue to give bitter, sweet or other taste sensation, when they dissolve in saliva. The taste buds shows the sensation of taste by signal transduction from the receptor organs. Now a days most of the potent drugs that are cardiac, analgesic, anti-inflammatory, anti-tubercular, antibacterial, anthalmetics, antimalarial, antiepileptics, anticoagulants, histamine receptor agonist, antithyroids, antineoplastic, antiprotozoal, diuretics, nutritional agents, opioid analgesic, sex hormones, vaccines most of them are bitter in taste. So it become a necessary to develop such a dosage form that is acceptable for its taste by patients especially children or geriatrics. It becomes a challenge for pharmacist to make palatable formulation by masking the bitter taste of the drug.

Keywords: Taste, taste buds, taste masking, ion exchange resin, taste masking technique, solid dispersion technique.