Abstract

FORMULATION AND IN VITRO EVALUATION OF FAST DISSOLVING TABLETS OF OLMESARTANMEDOXOMIL

Sheik Muddasar*, Dasari Prasad, Dr. Yasmeen, Dr.Sudhakar

Abstract

The objective of this research was to formulate fast dissolving tablets of Olmesartan medoxomil (Antihypertensive drug) for rapid action. Demand for fast dissolving tablets has been growing especially for elderly and children who are swallowing difficulties. The problem of certain fast dissolving tablets is their low physical resistance and high friability. In this investigation fast dissolving tablets are prepared by using 3 different super disinitegrants Crospovidone, Croscarmellose sodium, Sodium starch glycolate in 4%, 5% by 6% by direct compression technique. Prepared tablets were evaluated for pre and post compression parameters. All the formulations were evaluated for influence of disintegrates and their concentrations on the characteristics mainly on disintegration time and dissolution studies. Crospovidone in higher concentration showed, rapid disintegration, wetting and in vitro drug release as compared to other formulations.

Keywords: Olmesartan medoxomil, Fast dissolving tablets, Direct Compression method.