Abstract

SYNTHESIS OF SOME NOVEL 1,2,3- TRIAZINE FUSED THIOPHENES AS PROMISING ANTITUBERCULAR AND ANTICANCER LEADS

Saravanan Janardhanan* and Poornima K.

Abstract

In the present investigation, the synthesis and antitubercular and anticancer screening of 1,2,3- triazine fused thiophenes are aimed at. In this study, a twelve new bicyclic/tricyclic thiene-1,2,3-triazenes-4-ones (ADVJS 2a-2l) were synthesized by diazotization reaction with 2- amino-3-N-substituted carboxamido-4,5- disubstituted thiophenes (ADVJS -1a – 1l). The structures of these newly synthesized compounds were characterized by IR and 1H NMR studies. All the synthesized compounds were screened for their antitubercular and anticancer evaluation. From the present study it may be concluded that synthesized compounds are fruitful in terms of their structural novelty and marked biological activities.

Keywords: Triazine, Thiophene, Antirubercular, Anticancer, diazotization reaction.