Abstract

EFFECT OF RAPHANUS SATIVUS ROOT EXTRACT ON GLUCOSE TOLERANCE IN GLUCOSE-LOADED HYPERGLYCEMIC MICE

Asaduzzaman, Prashanta Kumer Paul, Shahadat Hossan, Shahnaz Rahman ,Mohammed Rahmatullah*

Abstract

In oral glucose tolerance test (OGTT), methanol extract of Raphanus sativus roots, when administered orally to glucose-loaded Swiss albino mice at doses of 50, 100, 200 and 400 mg/kg body weight led to dosedependent reductions in blood glucose levels. At these doses, the percent reductions in blood glucose levels were, respectively, 21.9, 34.0, 39.7, and 53.9% compared to control animals. A standard antihyperglycemic drug, glibenclamide, when administered at a dose of 10 mg/kg body weight reduced blood glucose levels by 49.2%. Preliminary phytochemical screening showed presence of alkaloids, flavonoids, and saponins in the extract, which components can be responsible for the observed blood glucose lowering effect.

Keywords: Raphanus sativus, OGTT, antihyperglycemic, glibenclamide, alkaloid, flavonoid.