Abstract

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF DIBENZALKETONE DERIVATIVES

Prabhudev S. M.*, Samina Sultana, Kishore Singh C., H. J. Kallur and Yasmeen B.

Abstract

The development of resistance to current Antimicrobial therapy continuous to stimulate the search for more effective agents, the increasing clinical importance of drug resistant and bacterial pathogens has lent additional urgency to microbiological research and development of biologically active compounds. Hence is to synthesize some Dibenzalketone constitute derivative and carry out Antimicrobial potentials with good activity and less toxic effects. Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds. Chalcone can be prepared by an aldol condensation between an aldehyde and a ketone in the presence of a catalyst. The conjugate base of an aldehyde or ketone adds to the carbonyl group of another aldehyde or ketone to give a β- hydroxyaldehyde or β-hydroxyketone product. The synthesized compounds were characterized by IR, 1HNMR & Mass Spectra’s, The presence of a reactive α, β-unsatutated keto function in chalcones was found to be responsible for their antimicrobial activity were screened by Disc Diffusion Method.

Keywords: Chalcones, Dibenzalketone, Antimicrobial activity.