Abstract

FORMULATION AND EVALUATION OF IMMEDIATE RELEASE AND CONTROLLED RELEASE ORAL FILM OF ANTI-HISTAMINE AGENT: LORATADINE

Rushi Somani*, Shraddha Kalyani and Yogesh Gavhane

Abstract

Innovations in oral drug delivery systems have made important contributions to medical practice by providing advances in the delivery of treatment with existing and novel drugs. The rate and extent of drug release and route of drug administration are vital parameters of any formulation. As Buccal delivery has more advantages over other routes of administration, such as providing immediate and prolonged and steadier drug levels, and less frequent dosing is required. It also has the ability to interrupt treatment by removing the film. Oral film of Loratadine which is antihistamine drug with immediate release and controlled release properties is prepared by solvent casting method, with the help of polymers such as HPMC E15, and PEG 400, Glycerin as a plasticize, SLS as a surfactant, Mannitol as sweetening agent, and citric acid as a saliva stimulating agent. The formulated oral film shows good Folding endurance, Swelling index, Surface pH, Weight variation, and Tensile strength.

Keywords: Buccal drug delivery systems, Immediate release, controlled release, antihistamine.