Abstract

A REVIEW ON SUSTAINED RELEASE DRUG DELIVERY SYSTEM

Kajal R. Patil*, Rajendra K. Surawase, Shivaraj B. Pagare, Suvarna S. Vadje and Mohini E. Shinde

Abstract

In all drug delivery system, Oral drug delivery remains the most preferred system for administration of various drugs. Sustained Release Drug Delivery System (SRDDS) is designed to release a drug at a predetermined rate by maintaining a constant drug level for a specific period of time with minimum side effects. The basic rationale of sustained release drug delivery system optimizes the biopharmaceutical, pharmacokinetic and pharmacodynamic properties of a drug in such a way that its utility is maximized, side-effects are reduced and cure of the disease is achieved. There are several advantages of sustained release drug delivery over conventional dosage forms like improved patient compliance due to less frequent drug administration, maximum utilization of the drug, increased safety margin of potent drug, reduction of fluctuation in steady-state drug levels, maximum utilization of the drug, increased safety margin of potent drug, reduction in healthcare costs through improved therapy and shorter treatment period. The present article contains brief review on various formulation approaches for Sustained release drug delivery system.

Keywords: Sustained release drug delivery system, Extended release, Reservior system