Abstract

CYCLIC VOLTAMMETRIC DETERMINATION OF ZOPICLONE IN PHARMACEUTICALS AND BLOOD SAMPLES USING GLASSY CARBON ELECTRODE

Dr. D. Srividya* and Dr. Vyshnavi Yelchuri

Abstract

Cyclic voltammetric, and differential pulse voltammetric techniques are used todetermination of zopiclone in pharmaceuticals and blood samples using glassy carbon electrode. It was selected to get reduction mechanism of >C=O< group. Zoplicone was examined in phosphate buffer over a pH range from pH 2.0 to pH 8.0 by differential pulse voltammetry and cyclic voltammetric methods. GCE showed one reduction peak at -0.6V with a peak reduction current of -4.5 μA using phosphate buffer solution at pH 6.0. No oxidation peak wasobserved at this potential in the reverse scan, suggesting that the electrochemical reaction is a totally irreversible process. The procedure was applied to the analysis of human blood samples.

Keywords: Zopiclone (ZPLN), acetonitrile, phosphate buffer, glassy carbon electrode, cyclic voltammetry, differential pulse voltammetry.