Abstract

SYNERGETIC ACTIVITY OF METHANOLIC EXTRACT OF SYZYGIUM CUMINI (L) SKEELS (SEEDS), COSTUS IGNEUS (NAK) (LEAVES), AND MUCUNA PRURIENS (L.) DC (SEEDS) FOR ANTIDIABETIC ACTIVITY.

Arjun .G*, Kiran.B, Yogisha.S

Abstract

In vitro evaluation of three plants viz., S. cumini (Seeds) C. igneus (Leaves) and M. pruriens (Seeds) showed a promising result in inhibition of α- Glucosidase tested at 0.0, 2.5, 5.0, 10.0, 20.0, 40.0, 80.0 and 160 μg/ml concentration. Moderate activity was recorded in 2.5, 5.0, 10.0 μg/ml concentration. 22.11 percent of inhibition was recorded in 20.0 μg/ml, 38.22 percent in 40.0 μg/ml, 42.11 percent in 80.0 μg/ml and 49.13 percent in 160.0 μg/ml. all the result was compared to standard acarbose. In aldose reductase inhibition assay tested at 5 to 320 μg/ml concentration showed significant activity and recorded 8.90 percent in 20.0 μg/ml, 12.33 percent in 40.0 μg/ml concentration. Highly significant activity was observed in 80, 160 and 320 μg/ml concentration and recorded 20.11, 24.55 and 34.55 percent respectively.

Keywords: S. cumini, C. igneus, M. pruriens, Anitdiabetic, ?- Glucosidase, aldose reductase.