Abstract

HAEMATINIC ACTIVITY OF DHASADEEBAAKINI CHOORANAM (A SIDDHA HERBO-MINERAL FORMULATION) IN PHENYL HYDRAZINE INDUCED ANAEMIC RATS

M. Subashini*, S.Gandhimathi, F.R. Shameem

Abstract

Anaemia is the most widespread nutritional problem in the world and is predominant in children, particularly in developing countries like India. Untreated anaemia may manifest as fatigue, reduced immunity, impaired memory and decreased quality of life. The gross incidence of anaemia in India called for formulation of an effective and safe traditional drugs to treat anaemia. One such medicine mentioned in the Siddha system of medicine is Dhasadeebaakini Chooranam. Hence, the present study was aimed to validate the haematinic activity of Dhasadeebaakini Chooranamin phenyl hydrazine induced anaemic rats. Anaemia was induced by an oral administration of phenyl hydrazine for a period of 5 days. The trial drugwas administered at the various dose levels of 200 mg/kg and 400 mg/kg orally to the animals for 14 days. Hb, RBC, PCV, MCV, MCH were analysed as indices of anaemia. Phenyl hydrazine significantly decreases the haematological parameters. After 14 days of treatment with the trial drug significantly reverse the haematological parameters and come towards the decreased values into normal levels. This result supports the traditional practice of Dhasadeebaakini Chooranam to treat anaemia.

Keywords: Haematinic activity, Dhasadeebaakini Chooranam, anaemia, phenyl hydrazine, Siddha.