Abstract

HEPATOPROTECTIVE EFFECT OF AYURVEDIC FORMULATION IN ANTITUBERCULOSIS DRUGS INDUCED HEPATOTOXICITY IN WISTAR ALBINO RATS

S. M. Kapgate* and A. B. Patil

Abstract

Introduction: Anti-tuberculosis drug induced hepatotoxicity is a major hindrance in the cure of tuberculosis. In conventional health science the therapeutic drug are withhold when evidence of liver damage is observed and is reintroduced after normalization of liver enzymes. Present article reports the hepato-protective effect of AYUHP, an Ayurvedic formulation in ATT induced hepatotoxicity in experimental study. Method: The test drug was administered in Wistar rats concomitantly with the ATT (combination of H=100mg/kg, R= 300mg/kg and Z=700mg/kg) drugs for 21 days. The test drug was assessed in two dose level and compared their effect on hepatotoxicity with known hepatoprotective drug Sylimarin. The assessment parameters used were AST, ALT, ALP, Tot. Bilirubin and histological examination of liver. Results: Significant reduction in AST and ALT was observed in group treated with AYUHP in both the dose levels as compared to ATT treated group which is comparable to standard hepatoprotective drug Sylimarin. In disease control group the swelling of hepatocytes, compressed & congested sinusoids, focal collection of lymphocytes & microphages near central vein was observed. In groups treated with AYU-HP & SY intact architecture of the liver tissue was noted. Conclusion: An herbal formulation AYU-HP has demonstrated hepatoprotective effect in Wistar albino rat model against anti-tuberculosis drug induced hepatotoxiicty.

Keywords: Anti-tuberculosis drugs, Hepatotoxicity, Herbal formulation, Hepatoprotective drugs.