Abstract

DETERMINATION OF POSSIBLE EFFECT OF (WATERMELON) CITRULLUS LANATUS SEED EXTRACT AGAINST SCOPOLAMINE INDUCED AMNESIA IN RATS

Alok Trivedi* and Dr. Amit Kishor Srivastava

Abstract

The present study designed to investigate the effect of Citrullus Lanatus (Watermelon) seed extract on pharmacological properties in Scopolamine-induced Amnesia in rats. A total of 20 female spragwe dawley rats were investigated into 5 equal groups as: group 1 (Normal control group) treated with distilled water (2ml/kg i.p.), Group 2 treated with Scopolamine received Scopolamine 1mg/kg for 15 days, Group 3 (Scopolamine+Citrullus Lanatus seed extract treatment group) received 1mg/kg bodyweight/day for 15 days, Group 4 (Scopolamine+Citrullus Lanatus seed extract) received 1ml/kg+100mg/kg bodyweight/day for 15 days, group 5 (Intact group or Per SE group) received Citrullus Lanatus seed extract of 300mg/kg bodyweight/day for 15 days. The Citrullus Lanatus (Watermelon) seed extract significantly restored learning impairments and memory functions in Scopolamine-induced in the Morris water maze test, elevated plus maze, Grip strength, and biochemicals tests in rats. Citrullus Lanatus seed has repairing effects on memory and behavioural disorders produced by Scopolamine and may have beneficial effects in the treatment of Amnesia disease.

Keywords: Acetyl Cholinesterase, Amnesia, Glutathione, Scopolamine, Citrullus Lanatus (Watermelon) seed extract.