Abstract

DEVELOPMENT AND EVALUATION OF GASTRORETENTIVE FLOATING BEADS OF SIMVASTATIN

*Ajay Kumar, Rahul Sharma and Dr. Jagdish Chandra Rathi

Abstract

Simvastatin is a lipid-lowering agent that is derived synthetically from a fermentation product of Aspergillus terreus. Simvastatin is a Hypolipidemic used to control elevated cholesterol or hypercholesterolemia. The primary uses of Simvastatin are for the treatment of dyslipidemia and the prevention of cardiovascular disease. Percentage yield of different formulation was determined by weighing the Floating beads after drying. The percentage yield of different formulation was in range of 63.4±0.3–76.1±0.4%. The maximum percentage yield was found in formulation F3, 76.1±0.4 as compare to all formulation. The drug entrapment efficacies of different formulations were in range of 64.85±0.25 - 75.45±0.47% w/w. The maximum drug entrapment was found in formulation F-3 (75.45±0.47). The results of measurement of mean particle size of optimized formulation F3 of floating beads was found to be 322.2 nm. Results of zeta potential of optimized formulation F3 of floating beads was found -23.4 mV. From the experimental study result, it was concluded that optimized batch F3 showed good entrapment efficiency and releases drug slowly and completely for 12 hours as beads remain in floating condition throughout dissolution study that assures prepared formulation remain floated in stomach without its early passing to lower GIT side. This will help to increase the residence time of Simvastatin in stomach i.e. in absorption window and achieve sustained release thereby increase the bioavailability of it.

Keywords: Simvastatin, Gastroretentive, Floating beads, Sustain release.