Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF ATENOLOL

Anshuman Yadav*, Anwar Iqbal Khan and Chanchal Jain

Abstract

The main objective of the present work was to develop sustained release matrix tablets of Atenolol. To improve the patient compliance & reduce the frequency of administration sustained release formulation of Atenolol is desirable. So sustained release Matrix Tablet of Atenolol was designed by using polymers such as Hydroxy Propyl Methyl Cellulose, Sodium Carboxy Methyl Cellulose and Guar Gum different ratio of drug and polymer were selected for the study. The IR study revealed that there was no chemical interaction between drug and excipients. The granules were prepared by wet granulation method. Precompressional parameters such as angle of repose, percent compressibility, and Hausner‟s ratios were studied. These results indicate that granules are having good flow property. After evaluation of physical properties like Weight variation, Hardness, Thickness, Friability of tablet, the formulations checked for the Percentage Drug content which have good uniformity. The in vitro release study was performed in phosphate buffer pH 7.4 up to 12 hrs. Dissolution data was analyzed by Percentage cumulative drug release. Matrix tablets studied for the different polymer ratios and performance checked for different concentration ratios. The results of drug dissolution studies showed improved drug release, retardation effects of the polymers and achieve better performance. It was observed that matrix tablets contained polymer blend of HPMC & Sodium CMC were successfully sustained the release of drug upto 12 hrs. Swelling Index of different formulations were studied. Stability studies (40±2ºC/75±5% RH) for 3 months indicated that Atenolol was stable in the matrix tablets.

Keywords: Atenolol, Precompression, frequency of administration, Drug content, retardation effect.