Abstract

REVIEW: A THERAPEUTIC APPLICATIONS OF MICROSPONGE DRUG DELIVERY SYSTEM

Parag A. Lekurwale*, Dr. Kanchan P. Upadhye, Anup R. Thakre and Krutika S. Bobde

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Abstract

More and more developments are being employed in the drug delivery systems to optimize its efficacy and cost-effectiveness of drug therapy. Peptides, proteins and DNA-based therapeutics can not be effectively delivered through conventional means. A Microsponges drug delivery system is a highly cross-linked, porous, polymeric system consisting of porous microspheres that can entrap and release them into the skin layers over a long period of time. Microsponges drug delivery system provides extended release with reduced irritation, improved thermal, physical and chemical stability. Microsponges drug delivery technology is used currently in cosmetics, skin care products, sunscreens and prescription products. One of the best feature of microsponge delivery system is it is self-sterilizing. Current review is focused on the method of preparation, characterization and various therapeutic applications of microsponges.

Keywords: Drug delivery System, Therapeutic Applications, Microsponges, quasiemulsion diffusion solvent method, suspension polymerization, controlled release system.