Abstract

SOLUBILITY ENHANCEMENT TECHNIQUE – A REVIEW

Priti B. Ghumre*, Sujata S. Bote, Shweta R. Kotgir, Apeksha B. Korde, Bhagyashri S. Bhosale and Rahul B. Chaudhari

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Abstract

Solubility is not to be confused with the capacity to dissolve or liquefy a substance, since this process may occur not only because of dissolution but also because of a chemical reaction. Low aqueous solubility is the major problem come across with formulation development of new chemical entities as well as for the generic development. Amongst all newly discovered chemical entities about 40% drugs are lipophilic and fail to reach therapeutic range due to their poor water solubility. Drug with poor solubility cause slow dissolution rates, generally show unreliable and limited absorption leading to low bioavailability when administered orally. A success of formulation depends on how competently it makes the drug available at the site of action. Solubility is the phenomenon of dissolution of solid in liquid phase to give a homogenous system. There are many methods which are used to enhance the aqueous solubility. The capacity to increase the aqueous solubility can thus be a valuable aid to increasing efficacy and / or reducing side effects of drugs. This is true for parenterally, orally and topically administered solutions. Hence various approaches are used for the enhancement of the solubility of poorly water soluble drugs. Choice of solubility improving method depends on drug property, site of absorption and requires dosage form characteristic. The purpose of this review article is to describe the methods of solubilization for the achievement of effective absorption and enhanced bioavailability.

Keywords: Solubility Enhancement, Dissolution, BCS classification, Bioavailability.