Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF FLOATING TABLET OF LEVOFLOXACIN

Dinesh Tanwar*, Dr. Jagdish Chandra Rathi and Rahul Sharma

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Abstract

Floating systems or hydrodynamic controlled systems are low-density systems that have sufficient buoyancy to float over the gastric contents and remain buoyant in the stomach without affecting the gastric emptying rate for a prolonged period of time. Levofloxacin pure drug is yellowish odorless, bitter crystalline powder, sparingly soluble in water and ethyl acetate, soluble in 0.1 N NaOH and 0.1N HCl and freely soluble in methanol, having melting point 218oC. λmax of levofloxacin was determined at 290 nm. Pre-compression Evaluation parameters were within the acceptable limit. The angle of repose of all the formulation was within 300. Post-compression Evaluation parameters were such as hardness, thickness, friability, drug content (%) and weight variation. The hardness value found between 4.8-5.3 Kg/cm2. The dissolution study of all formulations was found as the percentage drug release were F1- 88.53%, F2- 81.09%, F3- 95.74%, F4-83.12%, F5-82.12%, F6- 92.33 %, in 12 hrs. From all the formulation F3 showed excellent drug release with 95.74% release. F3 was considered as optimized formulation and subjected for kinetic modeling and stability studies. Formulations F3 was follow Zero Order release and diffusion mechanism with continuous drug release. Stability studies were carried out for the formulation F3 at 4±20C, 27± 2 0C and 45 ±2 0C for 45 days.

Keywords: Floating tablet, Levofloxacin, Pre-compression, Dissolution studies.