Abstract

FORMULATION AND EVALUATION OF FLOATING MICROSPHERE OF OFLOXACIN

Ashish Wagh*, Dr. Jagdish Chandra Rathi and Rahul Sharma

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Abstract

Floating microspheres have a bulk density less than gastric fluids and so remain buoyant in the stomach without affecting gastric emptying rate for a prolonged period of time were prepared. Pale yellow, bitter, odorless, amorphous powder of ofloxacin was observed λmax at 296nm. Drug ofloxacin was compatible and chemically stable as observed in FT-IR spectra. Five different formulations were prepared by o/w emulsion solvent evaporation method using different concentration of Ethyl Cellulose EC) and fixed amount (100mg) of ofloxacin and tween-80 (1%). Evaluation of floating microspheres formulations, EC- 4 has greater yield 95.43 % but its encapsulation efficiency was lower 74.6. EC-1, EC-2, EC-4 and EC-5 were possessed poor mircomeritic properties e.g. Carr’s Index 39.65, 37.65, 29.31 and 30.44% respectively, Hausner’s ratio 1.657, 1.604, 1.415 and 1438 respectively and angle of repose (θ) 31, 35, 28 and 29 respectively. Best formulation EC-3 microsphere batch possessed yield (91.69%), particle size (676 μm), and encapsulating efficiency (98.2), Carr’s Index (5.08%), Hausener’s ratio (1.054) and 65.2 % in-vitro buoyancy which was excellent among all prepared formulations. Also drug release was 97.913 %. Kinetic modeling revealed that floating microsphere batch EC-3 was followed Higuchi model with regression value (R2) 0.990.

Keywords: Floating Microsphere, Ofloxacin, Buoyancy, Floating Drug Delivery Systems.