Abstract

FORMULATION AND EVALUATION OF FLOATING TABLETS OF ACECLOFENAC

N. Ramya, A. Radha Krishna*, K. Venkatesh, B. Lakshmi, A. Iswarya, K. Jyothirmai, J. N. Suresh Kumar

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Abstract

In the past few years Gastro retentive drug delivery system (GRDDS) has topped the list of most focusing areas in the, novel drug delivery system (NDDS), as this is orally administered. This present work is focused primarily on formulation and evaluation of Aceclofenac floating drug delivery system (FDDS) inorder to improve the bioavailability, patient compliance and reduce the side effects. These tablets were prepared using various polymers like HPMC, Ethyl cellulose, Guar gum. A total of five formulations were prepared by using an effervescent material i.e. sodium bicarbonate. These prepared tablets were evaluated for hardness, total floating time, friability, floating lag time and invitro drug release studies. From the data obtained in these invitro drug release studies, formulation F1 shows good floating lag time (FLT), good invitro drug release.

Keywords: Floating lag time, Total floating time, HPMC, EC.