Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF HYDRALAZINE MOUTH DISSOLVING TABLET

Maneesh Kumar Kushwaha*, Jagdish Chandra Rathi and Rahul Sharma

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Abstract

Formulation and development of Mouth Dissolving Tablets (MDT) of Hydralazine that was dissolves or disintegrates within a minute in the oral cavity without the need of water and has a pleasant taste. Loading of hydralazine HCl on Tulsion 335 was carried out by batch process. Highest drug loading on resin was achieved when activated with both acid-alkali treatments. The absorption maxima of hydralazine HCl were observed at 220 nm. The thickness of the tablet was found 2.076 to 2.415 mm. The tablets with Crospovidone disintegrated faster than the tablets containing Ac-Di-Sol and sodium starch glycolate. The in vitro disintegration time of all the formulations varied between 20.66 ± 2.08 s to 66.33 ± 3.05 s. The in vitro wetting time of all the formulations varied between 18.66 ± 2.51 to 57.66 ± 3.51. in-vitro drug release experiments were performed at 37±0.5oC in paddle type dissolution apparatus. The results showed that all the formulations release the drug within 6 to 7 minutes. The maximum drug release was found in formulation FDT2 (98.747%). The order of drug release was found to be: FDT2 >FDT1 >FDT4 >FDT3 >FDT6 >FDT5.

Keywords: Hydralazine, Mouth Dissolving Tablet, evaluation, superdisintigrant.