Abstract

DEVELOPMENT AND EVALUATION OF TRANSDERMAL GEL OF FEMCYCLOVIR USING PENETRATION ENHANCER AND ALOE-VERA

Anurag Yadav*, Jagdish Chandra Rathi and Rahul Sharma

.

Abstract

Gel Formulations of famciclovir were prepared by simple mixing using stirrer with carbopol 940, HPMC K100M and aloe vera powder swelled in water intended for topical application. Famciclovir is an antiviral drug having higher protein binding, hepatic metabolism low bioavailability and low penetration power in skin. For preparation of gel formulations penetration enhancer (di sodium EDTA) was selected by solubility saturation method. Three trial batches were optimized on visual characters formulations CF-4, CF-5, HF-4, HF-5 and CHF-1 to CHF-5 were qualified. These qualified gel batches were further evaluated on ground of gel properties e.g. pH, Viscosity, Spreadability and % drug content, Formulations CF-4, CF-5, HF-4 and HF-5 showed % Drug content less than 90% hence removed from study. Formulation batches CHF-1 to CHF-5 were subjected for in-vitro drug release study, CHF-1(81.23%), CHF-2 (79.70%), CHF-3 (90.9%), CHF-4 (94.39%) and CHF-5 (92.82%). Though, all tested formulations showed good drug release profile but Regression value R² = 0.946 of CHF-4 revealed the CHF- 4 possessed excellent drug release. Different parameters were calculated for comparisons and finally the enhancement ratio was calculated that was 2.034. In-vitro drug release data of Gel batch CHF-4 was further expended for kinetic modeling.

Keywords: Transdermal Gel, Femcyclovir, Penetration Enhancer, Aloe-Vera.