Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLET OF ISONIAZID

Rahul Singh Kushwah*, Jagdish Chandra Rathi and Rahul Sharma

.

Abstract

Sustained release tablet of isoniazid was formulated and evaluated The study was begun with the drug analysis. The linearity was achieved in the concentration range of 4-20μg/ml in 0.1N HCl at 263 nm with regression coefficient of 0.995. Development was started with guar gum. At the same time to enhance the matrixing ability of the above MCC was also been used. After preformulation work, matrix tablets of drug were prepared by non aqueous wet granulation method. Initially the concentration of polymer was optimized to get better matrixing property and sustain release of the drug, prepared formulation G-1 to G-3 were evaluated and observed that it was not self sufficient to achieve desired matrixing ability for desired time. So further, MCC was also incorporated into the formulations to form GM-1 to GM-3. On the basis of obtained results and release of the drug formula GM-2 was selected with release of total 84.41% drug release. The drug formulation GM-2, the concentration of lactose was optimized as channeling agent. In this regard, Formulations GML-1 and GML-2 were prepared and evaluated in comparison to GM-2. The drug release study of the formulation GML-1 and GML-2 both are showing good release. Formulation GML-2 was taken for further study with release of 94.56%.

Keywords: Isoniazid, Antitubercular, Sustained release.