Abstract

FORMULATION AND EVALUATION OF MATRIX TYPE TRANSDERMAL DRUG DELIVERY OF PIOGLITAZONE

Vemula Vishal*, D. Prasad and Muvvala Sudhakar

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Abstract

Matrix type Pioglitazone Transdermal patches were prepared by solvent casting method using two different polymers i.e., Hydroxyl propyl methyl cellulose (HPMC) E 15 and Guar Gum. Polyethylene glycol is used as plasticizer and Dimethyl sulfoxide (DMSO) is used as penetration enhancer. The prepared formulations were subjected to various physicochemical evaluation tests such as weight variation, thickness, moisture content, moisture uptake, folding endurance, drug content. The in-vitro releases of the drug from the formulation were studied using cellophane membrane. It has been found that 89.09% of pioglitazone was released Invitro in the period of 12 hours. These findings suggest that delivery of pioglitazone through TDDS may overcome first pass effect and thus gives better glycaemic control in diabetic patients.

Keywords: Pioglitazone, HPMC, Guar Gum, Polyethylene glycol, Dimethyl sulfoxide, Solvent casting method.