Abstract

FORMULATION AND EVALUATION OF BILAYERED MUCOADHESIVE BUCCAL TABLETS OF CARVEDILOL

Grace Rathnam* and Swetha S.

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Abstract

The overall objective of present study was to formulate and evaluate bilayered mucoadhesive buccal tablets of Carvedilol using various bioadhesive polymers HPMCK100M, HPMCK4M, and carbopol. Ethyl cellulose was used as an impermeable backing membrane. The oral bioavailability of Carvedilol is (25% -35%) due to extensive first pass metabolism. Fourier Transform Infrared Spectroscopy analysis showed no evidence of drug excipients interaction. The formulations were prepared by direct compression and were evaluated for hardness, weight variation, drug content, surface pH, swelling studies, drug permeation, mucoadhesive strength and in vitro drug release. Physiochemical parameters like thickness (3.45-3.68 mm), weight variation (115.43-125.95 mg), hardness (53.2–65 N), friability (0.09–0.125 %) and drug content ((98.76–100.72%) were within the acceptable limits. The swelling index was reported to be in the range of 197.05–286.02 %, at 8 h. The surface pH of all the batches were in between 6.7 to 6.8. The mucoadhesive strengths (24.62–28.18 g) varied with the change in polymer concentrations especially of HPMC. From the data, it is evident that as the proportion of the polymer increases, the drug release was found to be reduced. In drug permeation study F3 showed slow and steady penetration of drug which resulted in 84 % at the end of 8 h. From this it is concluded that F3 showed promising results and Carvedilol bilayered mucoadhesive buccal tablets were prepared successfully using ethyl cellulose as a backing membrane.

Keywords: Carvedilol, buccal tablet, ethyl cellulose, HPMC K100M, HPMC K4M, Carbopol.