Abstract

AFTER CORONA-VIRUS, A NEW DISEASE IS AFFECTING CHILDREN, MULTISYSTEM INFLAMMATORY SYNDROME IN CHILDREN (MIS-C)

Vivek Kumar Paul*

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Abstract

New Delhi: India is already fighting the COVID-19 pandemic. However, to make matters worse, other deadly diseases are also starting to spread. The second wave of coronavirus is far from over but Black, White and Yellow Fungus has also wreaked havoc in the country. Meanwhile, another new disease is spreading. Even more frightening is that it is making small children its prey. Let's know everything about this disease. Introduction: Multi-system inflammatory syndrome' (MIS-C) has emerged as a new concern in children after recovering from COVID-19. Many organs of children are affected by this syndrome. The disease affects children a few weeks after they are infected with COVID-19. In the second wave of Corona, two cases of this disease in children has been witnessed. So far, this disease has been reported in 5 children. Objective: The aim of this systematic review was to analyse current literature and reported cases of multisystem inflammatory syndrome in children (MISC), concerning its clinical spectrum, complications associated, therapeutic strategies and distinguishing features of other clinical syndromes. Children recovering from corona-virus may be at risk of becoming infected with Multi-system inflammatory syndrome. Many organs of children are affected by this syndrome. Result: Common symptoms included gastrointestinal (70%), rash (57%) and cardiovascular (52% with shock). Notable differences with Kawasaki disease were identified including age, clinical presentation and cardiac involvement. Thirty per cent presented positive severe acute respiratory syndrome coronavirus-2 reverse transcription polymerase chain reaction and 51% positive serologies. Sixty-two per cent received intravenous immunoglobulin and 42% glucocorticoids. Sixty-two per cent required intensive care and 21 children died (<2%). Severe presentations were associated with neurological symptoms, hepatitis and acute kidney injury. Conclusion: MISC raises concern on its severe cardiac involvement at presentation, with frequent intensive care and immunomodulatory therapy need. Short-term outcomes seem to be favourable, with cardiac dysfunction recovery and low mortality rates.

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