Abstract

DRUG DESIGN: PHENOBOLA AS CLATHRIN MEIDATED ENDOCYTOSIS INHIBITOR AND EBOLA VIRUS TREATMENT

Mohammed Yonsif Mohammed, Abdulrhman A. Elshiekh, Maha M. Salim, Saoia A. I. Shaddad

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Abstract

Background: Ebola virus is a very serious contagious disease spread in Africa and other countries and it transmit by bats to human. Its symptoms range from fever to body organs bleeding.it outbreak started in many different places around the world. Aim: is to design a drug that block Clathrin mediated endocytosis (CME) cycle so as to prevent the virus from entering the body host cell. The virus uses the CME to enter and replicate. Material and Method: using ChemSketch to draw and determine the drug molecule, and using OpenBabel online server to transfer the molecule into MOL2 format so as to be apply in SwissDock server, then chose the target protein from protein database bank using PDB id of CME then insert in SwissDock and submit it to get the docking result. Result: a new drug that can prevent and bock the clathrin-mediated endocytosis (CME) cycle called Phenobola one of other CME blocker and inhibitor. And can treat Ebola virus by prevent entering into the host cell.

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