Abstract

DEVELOPMENT AND CHARACTERIZATION OF EMULGEL FOR TOPICAL DELIVERY OF 5-FLUOROURACIL

Manisha Verma*, Dev Sharan Chaturvedi, Neha Chaturvedi, Jeetendra Kushwaha, Manish Kumar Sahu

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Abstract

Object: Aim of this study was development and characterization of emulgel for topical delivery of 5-FU. Material & Method: different concentration of carbapol 940 was used for prepration of different form of emulgel. Result & Discussion: According to solubility parameter 5- FU was soluble in distilled water. Partition coefficient value of 5-FU is {PO/W = 16.85 x 10-2 for n-Octanol/ water, 12.96x10-2 for n- Octanol/PBS (pH 7.4) and 10.57x10-2 for n-Octanol/PBS(pH7.6)}. Acidic solution of 5-FU was scanned in UV visible spectophotometric method was found to be reproducible and highly sensitive. Standard curve of 5-FU was obtained the straight line. Correlation coefficient was found to be greater than 0.99. According to invitro study the release of drug from its emulsified gel formulation can be ranked in following descending order F2 > F1 > F4 > F3. Conclusion: All the detail parameters proved that developed 5-FU loaded transfersomal gel improve the skin absorption of 5-FU and provide better treatment of skin cancer.

Keywords: Emulgel, Carbapol 940, 5-Fluorouracil, Topical drug delivery.