Abstract

NOVEL DRUG DELIVERY SYSTEM OF HEMAGGLUTININ VACCINE

Kenny Nurmalia Brilliani*

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Abstract

The influenza virus is a respiratory disease spread by coughing or sneezing from an infected person by breathing from one patient to another. The global burden of 1 billion infections and between 3 and 5 million cases of severe illness caused by influenza epidemics is projected each year. There are currently two major types of influenza vaccine available: the inactivated vaccine (monovalent and protective against the strain A (H1N1)) and the live attenuated vaccine. Then a different influenza virus was isolated (influenza B) in 1940 and the first bivalent vaccine was tested in healthy adults. Many inactive vaccines are currently being developed in embryonic chicken eggs from propagation. However, a limiting factor is the availability of embryonated chicken eggs, and global production is not expected to meet the increasing demand for doses during the pandemic season. New influenza A strains with specific HA and NA were reported in the late 1970s. Since then, in most influenza vaccines, called trivalent influenza vaccine (TIV), two influenzas A strains (H1N1 and H3N2 subtypes) and one influenza B strain have been included (l.Barberis, 2013).

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