Abstract

PHYTOCHEMICAL SCREENING AND ANTIBACTERIAL ACTIVITY OF ALLIUM SATIVUM, CALOTROPIS PROCERA, ACACIA NILOTICA, AND MITRACARPUS SCABER MIXED HEXANE EXTRACTS

I. Sani*, F. Bello, D. Abdul-Kadir

Abstract

Plants remain the main sources of natural products for new therapies particularly in poor countries, because most of them are less cost, and can affect a wide range of infectious microorganisms, and another interesting reason is that, the herbal medicines have fewer adverse effects compared to the conventional ones. Therefore, plants are important sources of potentially useful substances for the development of new therapeutic agents. This work is aimed at evaluating the possibility of applying mixed hexane extracts of Allium sativum bulbs, Calotropis procera leaves, Acacia nilotica pods, and Mitracarpus scaber whole parts as antibacterial on some selected bacterial strains (Staphylococcus aureus, Klebsilla pneumoniae and Streptococcus pneumoniae). The efficacies of the mixed extracts were tested by using Agar well diffusion assay method and zones of growth inhibition were measured in millimetre (mm). Interestingly, the combination of the Four plants (synergetic effect) showed highest antimicrobial activity against the tested organisms (Staphylococcus aureus 6.5 ± 0.707; Klebsilla pneumoniae 12.5 ± 0.707; and Streptococcus pneumoniae 8.0 ± 1.414). Therefore, this study ascertained the value of these medicinal plants to be used as alternatives in the treatment of infections cause by the tested bacterial strains.

Keywords: Acacia nilotica pods, Allium sativum bulbs, Calotropis procera Leaves, Mitracarpus scaber, Mixed hexane extracts.