Abstract

RESTORATION OF NEPHROLOGICAL PARAMETERS BY FLEURYA AESTUANS LEAVES AND TETRAHYDROXYFLAVONE OF LEAD ACETATE INDUCED TOXICITY

*Charles C. Nwafor, Uzoma A. Ugonna, Solomon M. Uvoh and Asara A. Azibalua

.

Abstract

The impact of Fleurya aestuans hydroethanolic leaf extract and tetrahydroxyflavone against lead acetate-induced nephrotoxicity in Wistar rats was studied in this study. 55 Wistar rats weighing 110-170g were split into two phases. Group 1 (Control) got only ad libitum food and drink. Fleurya aestuans extract was given to groups 2,3,4 (50,75, and 200mg/kg). In phase two, Group A served as the control, Group B received only LA (2.25mg/kg), Groups C, D, and E were co-treated with LA (2.25mg/kg) and extract (50, 75, and 200mg/kg), Group F received LA and tetrahydroxyflavone (100mg/kg), and Group G received only tetrahydroxyflavone (100mg/kg). The rats were anesthetized with chloroform and sacrificed by cutting through the jugular vein. Blood samples were taken into heparinized vials for renal function test. Histological analysis of the kidneys was performed after they were extracted and processed. In comparison to the control group, the results showed that lead acetate significantly increased (p

Keywords: Fleurya aestuans, Tetrahydroxyflavone, Nephological Parameters, Kidney Dysfunctions.