Abstract

PATHOGENESIS OF LEPTOSPIROSIS-ASSOCIATED ACUTE KIDNEY INJURY

Ella Viani*

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Abstract

Leptospirosis is a disease caused by Leptospira, a genus from spirochaetes bacteria. It is transmitted to human through direct contact with contaminated water or soil by vector’s urine. About 10% cases can develop to severe forms including acute respiratory distress syndrome, pulmonary edema, hepatic failure, and acute kidney injury (AKI). The pathogenesis of leptospirosis-associated AKI including, direct effect of Leptospira, tubular alterations, prerenal AKI, hyperbilirubinemia, and rhabdomyolisis. Clinical manifestations in AKI of leptospirosis are characterized by the absence of oliguria and normal or reduced potassium serum.

Keywords: Leptospira, Leptospirosis, Pathogenesis, Acute Kidney Injury.