Abstract

DESIGN, SYNTHESIS AND PHARMACOLOGICAL EVALUATION NEW SERIES OF AZETIDINONE BASED PYRIMIDIN-2-ONE DERIVATIVES

Parth P. Patel*, Dharati D. Patel, Piyush J. Vyas and Suresh C. Ameta

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Abstract

Heterocyclic Compounds have so far been synthesized mainly due to the wide range of biological activities. Azetidinone plays an important role in biological field. From these reviews we synthesized a new series of 3-chloro-4-(3,4-dimethoxyphenyl)-1-{4-[6-(2-hydroxyphenyl) -2-oxo-1,2,5,6-tetrahydropyrimidin-4-yl]phenyl}azetidin-2-one derived from 3-chloro-4-(3,4-dimethoxyphenyl)-1-{4-[3-(substitutedphenyl) prop-2-enoyl]phenyl}-azetidin -2-one and urea using ethanol as a solvent. The title compounds were characterized by element analysis, and NMR spectral data. All the compounds were tested for their IR antibacterial and antifungal activities by broth dilution method.

Keywords: Azetidinone, IR, NMR, MTCC, broth dilution method.