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World Journal of Pharmaceutical Research (WJPR) is giving Best Article Award in every Issue for Best Article and Issue Certificate of Appreciation to the Authors to promote research activity of scholar.
Best Paper Award :
Dr. Dhrubo Jyoti Sen
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Abstract

EFFECT OF INTRATHECAL LEVOBUPIVACAINE AND BUPIVACAINE WITH FENTANYL ON POSTOPERATIVE AMBULATION AND ANALGESIA: A RANDOMIZED CONTROLLED TRIAL.

*Rishi Kumar Gautam, Rajesh Singh Rautela, Mahendra Kumar and Chhavi Sharma

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Abstract

Background: This study was conducted with the aim to compare Levobupivacaine and Bupivacaine in terms of ambulation and analgesic efficacy given by intrathecal route in patients undergoing lower abdominal surgery. Methods: Seventy patients belonging to ASA PS I & II were included undergoing lower abdominal surgery under subarachnoid block. They were randomly assigned to receive one of the following isobaric Levobupivacaine 10 mg or Bupivacaine 10 mg all combined with Fentanyl 25 µg. Surgery was allowed once the sensory blockade reached T10 level. Sensory changes and motor changes along with hemodynamic parameters were recorded. Time for successful ambulation was also noted. Results: Walk of 5 meters in a straight line was taken as the time for ambulation which was shorter in Levobupivacaine group with mean of 437.14±33.56 min collated with the mean of 460.29±21.75 min in group Bupivacaine which was statistically significant (p

Keywords: local anesthetics, intrathecal, lower abdominal surgery, subarachnoid, regional techniques.


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