Abstract

SYNTHESIS AND BIOLOGICAL EVALUATION OF 3- HYDRAZINYLQUINOXALINE2-(1H)-THIOL DERIVATIVES

Dharyappa Teli*, R. B. Kotnal, Sangappa Teli and S. M. Metri

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Abstract

We have chosen molecules with moieties possessing the antimicrobial activity of Quinoxaline derived from benzene. Its structure might be obtained by replacing a (c-s) moiety with an oxygen atom. Which is reported to have antibacterial and anti-Fungal activity and other nitropyridine ring attached to the para position of the Quinoxaline ring which possesses antibacterial, and antifungal activity. Present work deals with the preparation of 3-Hydrazinylquinoxaline2-(1H)-thiol is treated with hydrazine hydrate and nitropyridine gives 3-hydrazine-2- [(3-nitropyridin-2-yl) sulfanyl]- 1,2-dihydro quinoxaline and 2- [(3- hydrazine-1,2-dihydro quinoxaline-2yl) sulfanyl]-1- phenylethan-1-one. Hydrazides were synthesized to increase intracellular concentration and to try and decrease the resistance developed due to the decreased intracellular concentration of the drug these synthesized compounds were subjected to preliminary biological evaluation. The characterization of synthesized compounds was identified based on IR, 1HNMR, and Melting point. The compounds have been evaluated for antimicrobial activity and Anti-Fungal activity.

Keywords: Quinoxaline, Antimicrobial activity, Anti-Fungal Activity, Intracellular concentration.