Abstract

AN OVERVIEW OF BUCCAL DRUG DELIVERY IN FORM OF BUCCAL POUCHES

Samrah Khan* and Ashutosh Badola

.

Abstract

The Buccal drug delivery strategy involves administering medications through the cheek lining and dominant buccal mucosa. A handy route of administration for both systemic and local pharmacological activities is the buccal drug delivery system. Buccal drug delivery has attracted a lot of interest and momentum since it provides outstanding benefits. Due to strong patient compliance, a longer localised medication action, and the avoidance of gastrointestinal drug metabolism and first-pass elimination, drug administration via buccal mucosa is a desirable drug delivery technique. In order to allow for drug release and absorption in the moist environment of the oral cavity, buccal drug delivery systems must maintain close contact with the mucosa lining for an extended period of time. The purpose of the current work is to design buccal pouches for the treatment of mouth ulcers by placing the pouch between the cheek and upper gingiva (gums). These pouches have the tendency to aid drugs in bypassing the hepatic first-pass metabolism and entering straight into the systemic circulation. This method of drug delivery is thought to be beneficial for increasing drug bioavailability.

Keywords: .