Abstract

KEY CONSIDERATIONS, CHALLENGES, AND SOLUTIONS FOR SOFT GELATIN CAPSULES

Cigdem Acar*, Sulenur Ekmekci, Cuneyt Toprak, Gokay Gun and Erdinc Babuc

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Abstract

It is estimated that new chemical entities resulting of drug discovery process possess poor solubility and/or permeability. It leads to challenges for oral absorption of the molecules. The soft gelatin capsule dosage forms presents a chance to improve the oral bioavailibilty of poorly soluble compounds with a liquid matrix to make solubilize. However, formulation development and manufacturing process has a lot of challanges. The aim of this review is to help a formulator to understand the parameteres should be considered.

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