Abstract

A REVIEW ON COCRYSTALIZATION

Ch. Bhavani*, Kolimi Nikhil Kumar, Kaviti Shiva Shankar, Mandepelly Srivani and Dr. T. Rama Rao

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Abstract

Solubility is almost doubled compared to pure drug co-crystals and they showed faster dissolution. Comparison with poorly soluble formulations Polymorphic and co-crystalline bioavailability was significantly improved by more than 10-fold. The second issue that needs to be addressed is Substance solubility may still be advantageous over drugs. A higher Ksp indicates a higher co-crystal solubility. It has two or more different molecules arranged in a single crystal lattice. permeability, solubility, Melting point, stability, tableting and bioavailability can be improved by pharmaceuticals Co-crystal. For cocrystals, the coformer can be considered an impurity, so the solubility of the starting material may change. The adoption of solvent droplet extrusion technology has increased versatility the best As a result, investigation of crystal synthesis using suspension crystallization started in 2018. Comparing the solubility of the cocrystal with that of the starting material. Pure solvents, which are often not taken into account in the stated solubility values. Additionally, several peaks are visible in the DSC (differential scanning calorimetry) scan. Differential scanning calorimetryA DSC thermogram is essential to show the melting endotherm maxima of a sample.

Keywords: Pharmaceutical cocrystals, coformer, cocrystal characterization, crystal engineering.