Abstract

FORMULATION AND EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF PIRACETAM

*Lalitha A. and Abdul Nazeer M.

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Abstract

In present work attempts have been made to formulate controlled release matrix tablets of Piracetam by using natural & synthetic hydrophilic polymers, which is preferably used as ancognitive enhancer used in the treatment of Alzheimer’s disease. Controlled release matrix tablets were prepared by using polymers such as HPMC (Hydroxy Propyl Methyl Cellulose) K-15M, Xanthan gum, SCMC (Sodium Carboxy Methyl Cellulose) in different concentration by wet granulation technique. Piracetam meets all the ideal characteristics to formulate as matrix type controlled release drug delivery system. Piracetam is a highly effective cognitive enhancer used as a model drug to develop a controlled release formulation. Piracetam exhibits pH dependent solubility. It is more soluble in acidic pH and slightly soluble at neutral or alkaline condition (intestinal environment). The λmax of Piracetam was found to be 201nm in 0.1N hydrochloric acid. The Piracetam obeys the Beer’s law within the concentration of 5 to 25μg/ml. FTIR studies showed that there was no interaction between drug and polymers. The Controlled release matrix tablets were prepared by wet granulation method using different concentrations of gel forming natural & synthetic hydrophilic polymers. The formulated tablets were analyzed for pre compression and post compression parameter, swelling index, in-vitro drug release studies, in-vitro kinetics. The pre compression parameters of all the formulations were within the required limits was indicated good flow property, suitable for formulation of the tablets. The post compression parameters such as thickness, hardness, friability, uniformity of content and swelling index of all formulations were within the acceptable limits. F4 formulation was selected as best formulation based on in-vitro release studies, swelling studies, in- vitro release kinetics. The extent of drug release was found to be 99.75 in 12hrs. The drug release model of this formulation (F4) complies with zero order kineticsfollowed by Non-fickian diffusion mechanism. FTIR of selected best formulation shows that no interaction between the drug and polymers. Selected formulation showed controlled release profile than the conventional tablet (F14).

Keywords: Novel Drug Delivery, Controlled Release, Prolonged Action, Piracetam, Alzheimer’s disease.