Abstract

EVALUATION OF ANTI-DEPRESSANT ACTIVITY OF SEED EXTRACT OF ELEUSINE CORACANA L. IN EXPERIMENTAL RATS

Pramod Nikam, Vishnu A. Kangralkar*, Swagata Godabole, Damodar Goundar and Pratiksha Kelkar

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Abstract

Objective: Depression is a serious contributor to the global risk factor of disease and affects people in all communities, worldwide 20%`of total population is suffering from depression. Eleusine coracana L. is millet category, cultivated all over India having different pharmacological properties like hypoglycaemic, hypolipidaemic, wound healing, hepatoprotective, anticancer. In this study, antidepressant effect of both ethanolic and aqueous extracts of Eleusine coracana L. seeds was studied in rat. Method: Water wheel Model was used to evaluate effects of extracts in 200mg/kg to 400mg/kg by oral administration to rat. Result: 200-400mg/kg of both extract showed antidepressants effect. In this model Imipramine was used as a standard drug and result were compared with control. Conclusion: The information shows that seed of Eleusine coracana L. millet exert antidepressant like behaviour in rat. This can be attributed to the chemical constituents present in both extract of Eleusine coracana L. which are yet to be elucidated by fractionation studies.

Keywords: Depression, Eleusine coracana L., Water Wheel Model, Immobility time.